Diazoxide in treatment of hypertension.
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چکیده
منابع مشابه
Diazoxide in treatment of primary pulmonary hypertension.
Three patients with primary pulmonary hypertension and one man with suspected thromboembolic pulmonary hypertension were given up to 300 mg diazoxide by injection into the pulmonary artery. The three patients with primary pulmonary hypertension responded with a fall in total pulmonary resistance and a rise in cardiac output. The patient with suspected thromboembolic pulmonary hypertension did n...
متن کاملClinical Evaluation of Diazoxide: a New Treatment for Acute Hypertension.
THE effectiveness of ehlorothiazide and related compounds as diuretics and antihypertensive agents has been well established. Much confusion still exists, however, regarding the exact mechanisms by which these ag,ents reduce arterial pressure. Although it has not been fully established whether the reduction in arterial pressure following the thiazides is due solely to sodium diuresis,1 is secon...
متن کاملHazards of diazoxide in pulmonary hypertension.
The use of diazoxide in the treatment of pulmonary hypertension has been advocated recently. We describe three patients who responded less favourably. The first patient had cardiac arrest (asystole) after the acute bolus dose. After recovery only a slight increase in cardiac index was seen while pulmonary vascular resistance was unchanged. The second patient developed total atrioventricular blo...
متن کاملReversible Pulmonary Hypertension in an Infant Treated with Diazoxide
Background: Diazoxide is the main therapeutic agent for congenital hyperinsulinism. The drug is generally well tolerated; however, in this report severe adverse effects including heart failure (HF) and pulmonary hypertension (PH) in an infant are reported.Case report: A sixteen-day male infant with persistent hypoglycemia and with diagnosis of congenital hyperinsulinism underwent near total pan...
متن کاملDiazoxide concentration-response relation in hypertension.
The pharmacokinetic disposition and antihypertensive response of bolus infusions of diazoxide, 1, 2, or 4 mg/kg over 5, 10, or 20 seconds, were examined in seven patients with chronic stable essential hypertension and mean arterial pressures (MAP) between 122 and 155 mm Hg off therapy. Maximal reductions in MAP were noted 2 minutes after each dose, and a linear correlation was obtained in all p...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6035.584-a